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Master's Dissertation
DOI
10.11606/D.59.2010.tde-08062010-185911
Document
Author
Full name
Jader da Silva Barbosa
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2010
Supervisor
Committee
Constantino, Mauricio Gomes (President)
Carvalho, Ivone
Lopes, Joao Luis Callegari
Title in Portuguese
Estudo sobre a síntese de furanoliangolidos pela Reação de Diels-Alder
Keywords in Portuguese
furanoliangolidos
Reação de Diels-Alder
Abstract in Portuguese
Nosso grupo de pesquisa já vem há alguns anos estudando métodos para a síntese do núcleo estrutural dos furanoeliangolidos, mais especificamente do goiazensolido. A estrutura básica deste composto corresponde a um sistema 7-oxabiciclo [6.2.1] undecano, e ele possui atividades biológicas como esquistossomicida, citotóxica e antiinflamatória. Em nosso trabalho utilizamos como etapa chave a reação de Diels-Alder, que é geralmente eficiente e rápida para formação de sistemas policíclicos. Na ultima etapa da proposta sintética, propomos a clivagem da ligação interna do sistema policíclico para obtenção do macrociclo desejado.
Title in English
Studies on the synthesis of furanoheliangolides by Diels-Alder
Keywords in English
Diels-Alder reaction
Furanoheliangolides
Abstract in English
Our research group has been studying, for some years, new methods for the synthesis of the core structure of the furanoheliangolides, more specifically of goyazensolide. The basic structure of this compound is a 7-oxabicyclo [6.2.1] undecane system, and it shows biological activities such as schistosomicidal, cytotoxic and anti-inflammatory. In this work, we have used the Diels-Alder reaction as a key step, since it is usually fast and efficient for the synthesis of polycyclic structures. As a last step, we proposed that the cleavage of the internal bond of the rings should furnish the desired macrocycle.
 
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Dissertacao.pdf (1.19 Mbytes)
Publishing Date
2010-08-18
 
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