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Master's Dissertation
DOI
10.11606/D.59.2008.tde-24062008-194017
Document
Author
Full name
Vinícius Silveira Garcia
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2008
Supervisor
Committee
Serra, Osvaldo Antonio (President)
Baptista, Mauricio da Silva
Cardoso, Carmen Lúcia
Title in Portuguese
Derivados porfirínicos com potencial aplicação em terapia fotodinâmica. Alterações estruturais
Keywords in Portuguese
Derivados Porfirínicos
Diels-Alder
Fotofísica
Terapia Fotodinâmica
Abstract in Portuguese
Devido à sua intensa absorção de luz na região visível do espectro, as porfirinas e seus derivados (clorinas e bacterioclorinas) são de grande importância na terapia fotodinâmica (TFD) para o tratamento de doenças neoplásicas. Neste trabalho foram sintetizadas as novas vinil-porfirinas estrategicamente funcionalizadas (47 e 48), seguida de uma sistemática de reações de Diels-Alder com dieófilos ativados, com o propósito de obter clorinas e/ou bacterioclorinas para potenciais aplicações em TFD.
Title in English
Porphyrinic Derivatives with Potential Application in Photodynamic Therapy. Structural Modifications.
Keywords in English
Diels-Alder
Photodynamic Therapy
Photophysics
Porphyrin Derivatives
Abstract in English
Due to their strong absorption in the visible region, porphyrins and related derivatives (chlorins and bacteriochlorins) are very important in photodynamic therapy (PDT) for the treatment of neoplasic diseases. In this work were synthesized the novel and strategically functionalizated vinyl-porphyrins 47 and 48, followed by systematic Diels-Alder reactions with activated dienophiles to obtain chlorins and/or bacteriochlorins, potentially useful on PDT.
 
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GARCIAVS.pdf (1.40 Mbytes)
Publishing Date
2008-06-26
 
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