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Doctoral Thesis
DOI
Document
Author
Full name
Ludmila Macêdo Naud
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2019
Supervisor
Committee
Lotufo, Paulo Andrade (President)
Lima, Danielle Bivanco de
Pititto, Bianca de Almeida
Marchioni, Dirce Maria Lobo
Title in Portuguese
Consumo de ácidos graxos e álcool e sua relação com subfrações lipídicas quantificadas por ultracentrifugação vertical
Keywords in Portuguese
Bioética
Consumo de Álcool
ELSA-Brasil
Ingestão Alimentar
Perfil Lipídico
Abstract in Portuguese
Nesta tese, determinou-se o consumo alimentar e consumo de álcool de 2972 participantes de pesquisa do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Posteriormente foi identificada a relação da dieta e álcool com as subfrações de colesterol medidas por ultracentrifugação vertical, denominada Vertical Auto Profile (VAP). Foi identificada baixa associação dos ácidos graxos dietéticos e as subfrações de colesterol. Quanto ao consumo de álcool, independentemente do tipo de bebida alcóolica consumida, o álcool resultou em melhor perfil lipídico, com níveis significativamente maiores de HDL-colesterol, HDL2-colesterol e HDL3-colesterol, tanto em homens quanto mulheres. Também foi discutida a parte ética de pesquisas com seres humanos, contextualizando o caso do ELSA-Brasil.
Title in English
Consumption of fatty acids and alcohol and its relation with lipid subfractions quantified by vertical ultracentrifugation
Keywords in English
Alcohol consumption
Bioethics
ELSA-Brazil
Food Ingestion
Lipid Profile
Abstract in English
In this thesis, food and alcohol consumption of 2972 research participants from the Estudo Longitudinal de Saúde do Adulto (ELSA-Brazil) were determined. Subsequently, the relationship between diet and alcohol with cholesterol subfractions measured by vertical ultracentrifugation, called Vertical Auto Profile (VAP), was identified. Low association of dietary fatty acids and cholesterol subfractions has been seen. Regarding alcohol consumption, regardless of the type of alcohol consumed, alcohol resulted in a better lipid profile, with significantly higher levels of HDL-cholesterol, HDL2-cholesterol and HDL3-cholesterol, in both men and women. The ethical part of research with human beings was also discussed, contextualizing the case of ELSA-Brazil.
 
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Publishing Date
2019-07-02
 
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