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Doctoral Thesis
DOI
10.11606/T.61.2012.tde-26092012-153644
Document
Author
Full name
José Fernando Scarelli Lopes
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Bauru, 2012
Supervisor
Committee
Trindade Junior, Alceu Sergio (President)
Aiello, Carlos Alberto
Oliveira, Pedro Cesar Garcia de
Padovan, Luis Eduardo Marques
Pinto, Joao Henrique Nogueira
Title in Portuguese
Avaliação da biocompatibilidade da hidroxiapatita nanoparticulada no subcutâneo de ratos
Keywords in Portuguese
Biocompatibilidade
enxerto ósseo
hidroxiapatita
nanopartículas.
Abstract in Portuguese
Objetivo: O propósito do estudo é avaliar a biocompatibilidade de uma hidroxiapatita nanoparticulada em subcutâneo de ratos.Material e Métodos: A amostra foi constituída de 30 ratos brancos machos (Wistar) com aproximadamente 90 dias de vida com peso aproximado de 320 gramas. Foram inoculados 0,30 gramas de hidroxiapatita nanoparticulada no subcutâneo dos ratos e avaliados após eutanásia em microscopia óptica em 03, 07, 14, 21, 45 e 60 dias. Resultados: Não foi encontrada biocompatibilidade do material testado, porém o material foi totalmente reabsorvido após 45 dias, sem sinais de inflamação com características de tecido normal.
Title in English
Evaluation of nanoparticulate hydroxyapatite biocompatibility in subcutaneous tissue of rats
Keywords in English
Bone transplantations
durapatite
materials testing
nanoparticles.
Abstract in English
Objective: The aim is to evaluate the biocompatibility of a nanoparticulate hydroxyapatite in subcutaneous tissue of rats. Methods: The sample consisted of 30 male Wistar white rats aged between 90 days and weighing about 320 grams. 0.30 grams of nanoparticulate hydroxyapatite were inoculated in the subcutaneous tissue of the rats and after euthanasia a light microscopy evaluation was done in periods of 03, 07, 14, 21, 45 and 60 days. Results: Biocompatibility of the experimental material was not found, but it was completely reabsorbed in a period of 45 days, with no signs of inflammation and characteristics of a normal tissue.
 
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Publishing Date
2012-09-27
 
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