• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Mémoire de Maîtrise
DOI
https://doi.org/10.11606/D.75.2013.tde-30072013-092752
Document
Auteur
Nom complet
Monica Soto Monsalve
Adresse Mail
Unité de l'USP
Domain de Connaissance
Date de Soutenance
Editeur
São Carlos, 2013
Directeur
Jury
Deflon, Victor Marcelo (Président)
Marques, Clelia Mara de Paula
Pavan, Fernando Rogério
Titre en portugais
Síntese e caracterização de compostos de coordenação mistos de cobre com potencial atividade anti-Mycobacterium tuberculosis
Mots-clés en portugais
cobre (II)
ditiocarbazato
tiossemicarbazona
tuberculose
Resumé en portugais
No presente trabalho, foram estudadas duas series de complexos mistos de cobre (II). A primeira serie de complexos, constituída pelos ligantes 3-hidroxipicolinato e 2-acetilpiridinatiossemicarbazona N(4) substituída, sendo o substituinte variado pelos grupos ciclohexil, etil e fenil, ou o 2-acetilpiridinabenzilditiocarbazato. A segunda serie, constituída pelas mesmas tiossemicarbazonas e ditiocarbazato, com o ligante 2-hidroxinicotinato no lugar do 3-hidroxipicolinato. Com a finalidade de avaliar a atividade contra Mycobacterium tuberculosis.
Os complexos obtidos foram caracterizados em estado sólido, pelo ponto de fusão e por meio espectroscopia de absorção na região do infravermelho e difração de raios X em monocristais. Em solução foi utilizada a técnica de espectroscopia eletrônica.
Foi feito o estudo da atividade biológica dos 8 compostos obtidos contra o Mycobacterium tuberculosis, sendo todos eles candidatos ativos e promissores no combate à bactéria, já que apresentam todos valores baixos de concentração inibitória mínima. Sendo que os complexos 2 ,3, 4 e 6 apresentam atividade melhor do que alguns dos fármacos já usados no tratamento como ciprofloxacino, ácido p-aminosalicílico, cicloserina, gentamicina, etambutol, kanamicina, tobramicina, claritromicina e tiacetazona.
Titre en anglais
Synthesis and characterization of mixed copper compounds with potential anti-Mycobacterium tuberculosis activity
Mots-clés en anglais
copper (II)
dithiocarbazate
thiosemicarbazone
tuberculosis
Resumé en anglais
In the present work were investigated two series of mixed complexes of coppe (II). The first of them is constituted by the ligands 3-hydroxypicolinate and 2-acetylpyridinedithiosemicabazate or 2-acetylpyridinethiossemicrzones N(4) substituted, were the substituted groups consist on cyclohexyl, ethyl and phenyl. The second series is formed by the same thiosemicarbazones and dithiocarbazate, but with the ligand 2-hydroxynicotinate, instead of 3-hydroxypicolinate. This, in order to evaluate the activity against Mycobaterium tuberculosis.
The synthetized complexes have been characterized in solid state through the melting point and infrared spectroscopy and X-ray diffraction on single crystals. The characterization in solution was done by electronic spectroscopy.
Assays were performed to determine the biological activity of the eight compounds synthetized against the Mycobacterium tuberculosis. All complexes have shown low minimal inhibitory concentration, being promising candidates for successive tests. It is observed that complex 2, 3, 4 and 6 exhibit better activity than some of the drugs used in the treatment such as ciprofloxacin, p-aminosalicylic acid, cycloserine, gentamicin, ethambutol, kanamycin, tobramycin, thiacetazone and clarithromycin.
 
AVERTISSEMENT - Regarde ce document est soumise à votre acceptation des conditions d'utilisation suivantes:
Ce document est uniquement à des fins privées pour la recherche et l'enseignement. Reproduction à des fins commerciales est interdite. Cette droits couvrent l'ensemble des données sur ce document ainsi que son contenu. Toute utilisation ou de copie de ce document, en totalité ou en partie, doit inclure le nom de l'auteur.
Date de Publication
2013-10-10
 
AVERTISSEMENT: Apprenez ce que sont des œvres dérivées cliquant ici.
Tous droits de la thèse/dissertation appartiennent aux auteurs
CeTI-SC/STI
Bibliothèque Numérique de Thèses et Mémoires de l'USP. Copyright © 2001-2024. Tous droits réservés.