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Master's Dissertation
DOI
10.11606/D.85.2012.tde-08032013-141752
Document
Author
Full name
Larissa Andreto Marcato
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2012
Supervisor
Committee
Mesquita, Carlos Henrique de (President)
Hamada, Margarida Mizue
Vinagre, Carmen Guilherme Christiano de Matos
Title in Portuguese
Dosimetria interna para o [4-14C] - colesterol em humanos
Keywords in Portuguese
dosimetria interna
modelo dosimétrico
[4-14C]-colesterol
Abstract in Portuguese
O principal objetivo deste trabalho é fornecer um modelo biocinético validado em termos fisiológicos para a avaliação das doses radiométricas devido à ingestão de [4-14C]-colesterol em humanos. Com o intuito de validar o modelo biocinético proposto para o [4-14C]-Colesterol, os valores de excreção fecal e absorção preditos pelo modelo foram comparados com dados experimentais da literatura, foi obtido um alto grau de concordância entre os resultados de acordo com teste ANOVA (p = 0,416 para os valores de excreção e p = 0,423 para os valores de absorção). Foram calculados os coeficientes de Dose Efetiva (SvBq-1), Dose Equivalente (SvBq-1) e Dose Absorvida (GyBq-1) nos orgãos e tecidos para humanos utilizando a metodologia MIRD e o software de análise compartimental ANACOMP para quatro objetos simuladores que representam: um adulto com massa de 73,3 kg, um adolescente de 15 anos (56,9 kg), uma criança de 10 anos (33,2 kg) e uma criança de cinco anos (19,8 kg). O órgão que obteve a maior Dose Absorvida, para todos os objetos simuladores, foi o intestino grosso inferior (IGI). O conceito da alometria foi utilizado para interpolar o Coeficiente de Dose Absorvida no intestino grosso inferior (DIGI) para massas corpóreas (m) desconhecidas: DIGI(SvBq-1)=161,26.m(kg)-1,025. Para uma mesma quantidade administrada de colesterol, o Coeficiente de Dose Efetiva (E) diminui com o aumento da massa corporal do objeto simulador, em outras palavras, para a mesma atividade administrada os indivíduos com menor massa são submetidos a Doses Efetivas mais elevadas. O conceito de alometria também foi utilizado para interpolar o Coeficiente de Dose Efetiva (E) para massas corpóreas (m) desconhecidas: E(SvBq-1)= 171,1.m(kg)-1,021.
Title in English
Internal dosimetry for [4-14C]-cholesterol in humans
Keywords in English
dosimetric model
internal dosimetry
[4-14C]-cholesterol
Abstract in English
The main objective of this work is to provide a biokinetic model in order to estimate the radiometric dose due to intake of [4-14C]-cholesterol. The model was validated comparing the values of fecal excretion and absorption described in literature with that predicted by the model. The proposed model achieved good concordance between the results (p = 0.416 for excretion and p = 0.423 for absorption). The coefficients of Effective Dose (SvBq-1), Equivalent Dose (SvBq-1) and Absorbed Dose (GyBq-1) in human organs and tissues were calculated using the MIRD methodology and the compartimental analysis software ANACOMP. The coefficients were estimated for four phantoms: (i) adult with a body mass of 73.3 kg, (ii) 15 years old adolescent (56.9 kg), (iii) 10 years old child (33.2 kg) and (iv) five years old child (19.8 kg). The organ that received the highest Absorbed Dose for all phantoms was the lower large intestine (LLI). The allometry theory was used to interpolate the coefficient of absorbed dose in the lower large intestine (DLLI) for unknown body mass (m): DLLI (GyBq-1)=161.26 m (kg)-1.025. For the same administered activity, the Effective Dose Coefficient (E) decreases as the body mass increases. On other words, for the same intake activity, individuals with low body mass are exposed to higher doses. The allometry theory was used to interpolate the coefficient Effective Dose (E) for unknown body mass (m): E(SvB-1)= 171.1 m(kg)-1,021.
 
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Publishing Date
2013-03-26
 
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