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Doctoral Thesis
DOI
10.11606/T.87.2012.tde-13122012-141110
Document
Author
Full name
Mônica Larucci Vieira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2012
Supervisor
Committee
Nascimento, Ana Lucia Tabet Oller do (President)
Baldini, Regina Lúcia
Faria, Fernanda
Martinez, Marina Baquerizo
Tavassi, Ana Marisa Chudzinski
Title in Portuguese
Interação de Leptospira interrogans com o sistema proteolítico plasminogênio/plasmina: análise, caracterização e possíveis implicações na infecção.
Keywords in Portuguese
Bactérias patogênicas
Infecções bacterianas
Leptospirose
Virulência
Abstract in Portuguese
A leptospirose é uma zoonose causada por bactérias patogênicas do gênero Leptospira. Apesar de sua importância, a patogênese e virulência permanecem não elucidadas. As leptospiras não apresentam proteases conhecidas de degradação de matriz extracelular, atividade crucial para a penetração e disseminação nos hospedeiros. Assim, foi proposta a investigação da interação de leptospiras com plasminogênio/plasmina e as implicações para a infecção. As leptospiras capturam plasminogênio na superfície, e este é convertido à plasmina por ativadores do hospedeiro. A plasmina associada propicia degradação de componentes de matriz extracelular, habilidade de penetração e evasão imune. Adicionalmente, as leptospiras estimulam a expressão de ativadores de plasminogênio e metaloproteases de matriz. Os resultados contribuem para o conhecimento do processo infeccioso das leptospiras, descrevendo um novo mecanismo de patogenicidade.
Title in English
Leptospira interrogans interactions with the plasminogen/plasmin proteolytic system: analysis, characterization and possible implications for the infection.
Keywords in English
Bacterial infections
Leptospirosis
Pathogenic bacteria
Virulence
Abstract in English
Leptospirosis is a zoonosis caused by pathogenic bacteria from genus Leptospira. Despite its importance, the pathogenicity and virulence remain to be elucidated. The leptospires do not present known proteases able to degrade extracellular matrix, an activity essential for the penetration and dissemination within the hosts. Therefore, we proposed the investigation of the leptospiral interaction with plasminogen/plasmin and its implications for infection. Leptospires capture plasminogen on the surface, which is converted to plasmin by hosts activators. Surface-bound plasmin confers extracellular matrix components degradation, penetration ability and immune evasion. Additionally, leptospires stimulate plasminogen activators and matrix metaloproteases expressions. The results constitute one possible mechanism that contributes to the invasion process and the rapid dissemination of Leptospira.
 
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Publishing Date
2012-12-18
 
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