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Master's Dissertation
DOI
10.11606/D.87.2008.tde-24092008-065657
Document
Author
Full name
Norberto Carone Castro Junior
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Gonçalves, Luis Roberto de Camargo (President)
Hayashi, Lia Siguemi Sudo
Nascimento, Nanci do
Title in Portuguese
Comparação do potencial neutralizante dos soros antibotrópico comercial e experimental frente às atividades biológicas dos venenos de Bothrops jararaca e Bothrops erythromelas
Keywords in Portuguese
associação farmacológica
Bothrops erythromelas
drogas antiinflamatórias
edema
soro antibotrópico
soroterapia
Abstract in Portuguese
Na região nordeste é registrado o maior índice de letalidade por acidentes ofídicos do Brasil. As serpentes Bothrops erythromelas (Be) são as responsáveis pela maioria dos acidentes na região, e o veneno dessa serpente não integra o pool de antígenos utilizado pata a obtenção do soro antibotrópico (SAB). Nesse estudo avaliou-se a potência do SAB na neutralização de algumas atividades do veneno (V) de Be. Os resultados mostraram que o SAB neutraliza as atividades do VBe, mas, exceto para a atividade coagulante e letalidade, a potência do SAB foi significativamente menor, quando comparado à neutralização das mesmas atividades do veneno de B. jararaca. A utilização de um soro obtido após a inclusão do VBe ao pool de antígenos não melhorou significativamente a potência do SAB. O SAB neutralizou também o edema inflamatório induzido pelo VBe, mas a associação do SAB à dexametasona inibiu o edema quando aplicado até 45 min após o envenenamento. Nesse tempo, SAB ou dexametasona aplicados isoladamente não foram efetivos em diminuir esse edema.
Title in English
Comparison of the neutralizing potential of the commercial and experimental anti-botropic serum front the biological activities of the Bothrops jararaca and Bothrops erythromelas venom.
Keywords in English
Anti-botropic serum
Antiinflamatory drugs
Bothrops erythromelas
Edema
Pharmacological association
Serum therapy
Abstract in English
In the northeast region is registered the higher lethality index by snakebites in Brazil. Bothrops erythromelas (Be) snakes are responsible for the larger number of snakebites in that region, and the venom of these snakes do not integrate the pool of antigens used to obtaining the Bothrops antivenom (BAV). In the present study, the potency of this serum in neutralizing some activities of Be venom (V) was evaluated. Results showed that BAV neutralizes BeV activities, but, except for coagulant activity and for lethality, the potency of the BAV was significantly lower, when compared to the neutralization of the same parameters of the Bothrops jararaca venom. The use of antivenom obtained after inclusion of BeV to the pool of antigens did not ameliorate the BAV potency. The BAV also neutralizes the inflammatory edema induced by BeV, but the association of BAV and dexamethasone decreased the edema when applied up to 45 min after the venom. At this time, antivenom or dexamethasone administered alone were ineffective in inhibiting this edema.
 
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Publishing Date
2009-02-17
 
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