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Doctoral Thesis
DOI
10.11606/T.9.1982.tde-25032008-123623
Document
Author
Full name
Jorge Mancini Filho
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1982
Supervisor
Committee
Lajolo, Franco Maria (President)
Angelis, Rebeca Carlota de
Domingues, Joao Baptista
Qualifik, Paul
Souza, Nelson de
Title in Portuguese
Efeito das fito-hemaglutininas de feijões (Phaseolus vulgaris L.) sobre a mucosa intestinal
Keywords in Portuguese
Enterócitos
Feijões
Lectinas
Mucosa intestinal
Proteínas
Abstract in Portuguese
Não consta resumo na publicação
Title in English
Effects of phytohemagglutinins from phaseolus beans (P. vulgaris L.) on intestinal mucosa
Keywords in English
Enterocytes
Intestinal mucosa
Phaseolus beans
Phytohemagglutins
Proteins
Abstract in English
Biological and immunological properties of phytohemagglutins from two brazilian varieties of beans (Phaseolus vulgaris) were studied. Through immunoprecipitation in agar gel, immuoenzymatic assays (ELISA) and eletrophoretic behavior after affinity chromatography purification it was shown that the lectins are similar. Both lectins when given to rats are toxic. They reduce growth and intestinal dissacharidase activity. They also able to smooth the "microvillous" of the enterocyte and to induce the appearance of autophagosomes in the enterocyte citoplasm. All this modification result in a reduced rate of carbohydrates absorption either in "vitro" or "in vivo".
 
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Publishing Date
2008-03-26
 
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