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Master's Dissertation
DOI
10.11606/D.9.1985.tde-11072011-112744
Document
Author
Full name
Telma Mary Kaneko
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1985
Supervisor
Title in Portuguese
Influência de agentes suspensores e edulcorantes na suspensão de estearato de eritromicina
Keywords in Portuguese
Boniasol 2600
Glicerina
Sacarose
Sorbitol 70%
Suspensão (Formas farmacêuticas)
Suspensão de estearato de eritromicina
Veegum HV
Viscosol RV
Abstract in Portuguese
As suspensões de estearato de eritromicina, de procedência nacional, apresentam a inconveniência que reside na elevada viscosidade ou flutuação do fármaco disperso. Foram estudados diferentes adjuvantes farmacotécnicos, a fim de verificar fatores interferentes que poderiam melhorar a estabilidade da suspensão de estearato de eritromicina. Como agentes suspensores foram utilizados BoniasolR2600 (carboximetilcelulose sódica), veegumR HV (silicato de alumínio e magnésio) e ViscosolR RV (glicolato de amido sódico) e como edulcorantes a glicerina, sorbitol a 70% e sacarose. As determinações analíticas para avaliar a estabilidade das suspensões foram: pH, densidade, viscosidade, aspecto da suspensão, volume do fármaco disperso, características de ressuspensão e doseamento do antibiótico. As suspensões contendo BoniasolR 260 e glicerina ou sorbitol não apresentaram o fenômeno da flutuação. As preparações contendo VeegumRRV e glicerina ou sorbitol na concentração de 30% (p/v) apresentaram estabilidade adequada.
Title in English
Influence of suspending agents and sweeteners in erithromycin stearate suspension
Keywords in English
Boniasol 2600
Erithromycin stearate suspension
Glycerin
Sorbitol 70%
Sucrose
Suspension (Pharmaceutical forms)
Veegum HV
Viscosol RV
Abstract in English
Suspensions of erithromycin stearate of national origin present the inconvenience of the high viscosity or of the flotation of the dispersed drug. Different pharmaceutical helpers were studied in order to verify of the erythromycin stearate suspension. BoniasolR2600 (sodium carboxymethyl cellulose), VeegumR HV (aluminum magnesium silicate) and ViscosolR RV (sodium starch glycollate) were used as suspending agents and glycerin, sorbitol at 70% and sucrose were used as sweeteners. Analytic determination to evaluate the suspensions stability were: pH, density, viscosity, aspecto of suspension, volume of the dispersed drug, resuspension characteristics and determination of the antibiotic dose. Suspensions containing BoniasolR 2600 and glycerin or sorbitol didn't present floatation. Preparation with veegumR HV and glycerin or sorbitol in a concentration of 30% (p/v) presented adequate stability.
 
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Publishing Date
2011-07-11
 
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