Quantificação de MDMA em amostras de ecstasy por cromatografia em fase gasosa (GC/NPD)

Lapachinske, Silvio Fernandes

doi:10.11606/D.9.2004.tde-05082004-162808

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Master's Dissertation

DOI

https://doi.org/10.11606/D.9.2004.tde-05082004-162808

Document

Master's Dissertation

Author

Lapachinske, Silvio Fernandes (Catálogo USP)

Full name

Silvio Fernandes Lapachinske

E-mail

Institute/School/College

Faculdade de Ciências Farmacêuticas

Knowledge Area

Toxicology and Toxicological Analysis

Date of Defense

2004-03-31

Published

São Paulo, 2004

Supervisor

Moreau, Regina Lucia de Moraes (Catálogo USP)

Committee

Moreau, Regina Lucia de Moraes (President)
Chasin, Alice Aparecida da Matta
Silva, Maria Teresa de Araujo

Title in Portuguese

"Quantificação de MDMA em amostras de ecstasy por cromatografia em fase gasosa (GC/NPD)"

Keywords in Portuguese

3,4-metilenodioximetanfetamina
ecstasy
quantificação

Abstract in Portuguese

Quimicamente, o ecstasy é a 3,4-metilenodioximetanfetamina (MDMA), um composto sintético com propriedades estimulante central e alucinogênicas. Algumas substâncias análogas à MDMA, já identificadas em comprimidos de ecstasy, são principalmente: 3,4-metilenodioxietilanfetamina (MDEA), 3,4-metilenodioxianfetamina (MDA), metanfetamina e anfetamina. Os adulterantes mais comuns, normalmente encontrados são: cafeína e efedrinas. O objetivo deste trabalho foi a validação de um método analítico para quantificar a MDMA em comprimidos e cápsulas de ecstasy, através da cromatografia em fase gasosa com detector de nitrogênio/fósforo (GC/NPD). Substâncias análogas à MDMA e adulterantes também foram identificados. Amostras de comprimidos e cápsulas de 25 diferentes lotes, apreendidos como ecstasy em São Paulo (SP), foram analisadas pelo método proposto. Desse total de amostras, 21 continham somente MDMA (84%) e apenas 1 delas apresentou MDMA associada com cafeína (4%). A concentração total de MDMA nessas amostras variou entre 30,9 e 92,7mg, resultando em uma média aritmética de 63mg.

Title in English

Quantification of MDMA in ecstasy samples by gas chromatography (GC/NPD)

Keywords in English

3,4-methylenedioxymethamphetamine
ecstasy
quantification

Abstract in English

Chemically, "ecstasy" is 3,4-methylenedioxymethamphetamine (MDMA), a synthetic compound with stimulant and hallucinogenic properties. Some MDMA analog substances such as 3,4-methylenedioxyethylamphetamine (MDEA), 3,4-methylenedioxyamphetamine (MDA), methamphetamine and amphetamine have already been identified in "ecstasy" tablets. Caffeine and ephedrines are the most common adulterants also found. The aim of this paper is to describe the validation of an analytical method to quantify MDMA in "ecstasy" tablets and capsules. Gas chromatography with nitrogen/phosphorus detector was used in the method. Analog substances to MDMA and adulterant compounds were also identified. Samples from 25 lots of tablets seized in the city of São Paulo were analyzed. From that total, 21 showed only MDMA (84%) and just 1 of them presented MDMA plus caffeine (4%). MDMA total concentration in these samples had a variation between 30.9 and 92.7mg, resulting in an arithmetic average of 63mg.

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Publishing Date

2004-10-06

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