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Master's Dissertation
DOI
10.11606/D.9.2004.tde-26092006-102030
Document
Author
Full name
Monica Silva dos Reis Turolla
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Nascimento, Elizabeth de Souza (President)
Freitas, Paulo Chanel Deodato de
Salvadori, Myriam Clara
Title in Portuguese
Avaliação dos aspectos toxicológicos dos fitoterápicos: um estudo comparativo
Keywords in Portuguese
aesculus hippocastanum
cimicifuga racemosa
ginkgo biloba
hypericum perforatum
medicamentos fitoterápicos
panax ginseng
passiflora incarnata
piper methysticum
plantago ovata
plantas medicinais
Rhamnus purshiana
Valeriana officinalis
Abstract in Portuguese
Esta Dissertação apresenta informações gerais sobre os medicamentos fitoterápicos e os aspectos toxicológicos de uma amostra de dez plantas medicinais comercializadas como medicamentos fitoterápicos no Brasil, pesquisados junto aos principais bancos de dados e fontes públicas de informação. A análise dos medicamentos fitoterápicos cobre as dimensões histórica, econômica e farmacêutica. No tocante aos aspectos toxicológicos, foram avaliados os dados de toxicidade pré-clínica de dez plantas selecionadas, e realizado um levantamento das informações publicadas para Hypericum perforatum e Piper methysticum, relacionadas ao termo toxicidade, segundo três importantes bancos de dados. Adicionalmente, este trabalho aborda as propostas para realização de ensaios de toxicidade pré-clínica para os fitoterápicos segundo a OMS e legislação brasileira, e as normas para avaliação de substâncias químicas segundo a OECD.
Title in English
Evaluation of toxicological aspects of the herbal medicines:a comparative study
Keywords in English
aesculus hippocastanum
cimicifuga racemosa
ginkgo biloba
herbal medicines
hypericum perforatum
medicinal plants
panax ginseng
passiflora incarnata
piper methysticum
plantago ovata
rhamnus purshiana
toxicological aspects
Valeriana officinalis
Abstract in English
This thesis presents general information on herbal medicines and on the toxicological aspects of a sample of ten medicinal plants traded as herbal medicines in Brazil. The survey was carried out in the main databases and public sources of information. The analysis on the herbal medicines encompasses the historical, economic and pharmaceutical dimensions. In what concerns toxicological aspects, data on pre-clinical toxicity were evaluated for Hypericum perforatum and Piper methysticum, these keywords being related to toxicity in three important databases. In addition, this study discusses the proposals for pre-clinical toxicity trials on herbal medicines according to WHO and the Brazilian legislation, and the standards for evaluation of chemical substances according to OECD.
 
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Publishing Date
2006-12-07
 
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