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RNA binding protein (RBP) is a class of proteins closely related to gene expression, directing RNA splicing, maturation, transportation, and degradation. Despite its importance in post transcriptional regulation, little is known about the genetic basis of the regulation of these genes. In this work we use quantitative genetic approaches to identify which genes or regulatory elements are associated with variation in the expression of RBP-coding genes. We show that the regulation of these genes is highly modular, and the expression of subgroups of RBP-coding genes share QTLs among themselves but not with other subgroups.