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Doctoral Thesis
DOI
Document
Author
Full name
Omar Julio Sosa
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2019
Supervisor
Committee
Reis, Eduardo Moraes Rego (President)
Brentani, Helena Paula
Kimura, Edna Teruko
Krepischi, Ana Cristina Victorino
Silva, Israel Tojal da
Title in Portuguese
Identificação e anotação funcional de novos transcritos com expressão alterada no câncer pancreático
Keywords in Portuguese
Câncer pancreático
RNA-Seq
Transcritômica
Abstract in Portuguese
Neste estudo foi implementado um pipeline bioinformático para processar e analisar dados de RNA-Seq total e fita-específico gerados em nosso laboratório a partir de amostras pareadas de tumor e tecido adjacente não tumoral de 14 pacientes com o objetivo de catalogar com alta-resolução a composição e alterações no transcritoma no PDAC incluindo genes codificadores e não codificadores de proteína.
Title in English
Identification and functional annotation of novel transcripts with altered expression in pancreatic cancer
Keywords in English
Pancreatic cancer
RNA-Seq
Transcriptomic
Abstract in English
In the present work, we applied a bioinformatic pipeline to process and analyse data from total RNA-seq strand-oriented generated in our laboratory from matched samples of tumor and non-tumor adjacent pancreatic tissue from 14 patients with the goal of generate a high resolution catalog of the composition and the alterations in the transcriptome of PDAC, including protein coding and non coding genes.
 
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Publishing Date
2019-04-30
 
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