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Master's Dissertation
DOI
https://doi.org/10.11606/D.9.1975.tde-18042024-151919
Document
Author
Full name
Tatsuya Sakuma
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1975
Supervisor
Title in Portuguese
"Determinação do Ácido 3-Metoxi-4Hidroximandélico Urinário (Ácido Vanilmandélico) por Eletroforese de Baixa Voltagem em Papel".
Keywords in Portuguese
Ácido 3-Metoxi-4Hidroximandélico; catecolaminas; feocromocitoma; ganglioneuroma; adrenalina; noradrenalina
Abstract in Portuguese
A determinação do VMA urinário é importante para diagnóstico de feocromocitoma, ganglioneuroma e meuroblastoma.Descreve-se um método simples e econômico para determinação desse metabólito urinário daseado na modificação do método de EICHHORN & RUTENBERG. Pela modificação proposta conseguiu-se a redução do tempo de análise de 17 horas para 5 horas.
Title in English
Determination of Urinary 3-Methoxy-4Hydroxymandelic Acid (Vanylmandelic Acid) by Low Voltage Paper Electrophoresis
Keywords in English
3-Methoxy-4Hydroxymandelic Acid; catecholamines; pheochromocytoma; ganglioneuroma; adrenaline; noradrenaline
Abstract in English
The determination of the urinary excretion of vanilmandelic acid is important for the diagnosis of pheochromocytoma, ganglioneuroma and neuroblastoma. A simple and economic method is described for the analysis of this urinary metabolite, based upon a modification of the technique of EICHHORN & RUTENBERG. The modified method is shown to be comparable to the original technique both in precision and specificity. There is no interference from vanillin in the food and therefore no necessary for dietary restrictions, usually required in other analytical processes. The proposed modification reduces the time of analysis from 17 hours to 5 hours.
 
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Publishing Date
2024-05-29
 
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